75507-26-5
- Product Name：2-(Hydroxymethyl)-12-crown 4-Ether
- Molecular Formula：C9H18O5
- Purity：99%
- Molecular Weight：206.239
Product Details
Appearance:clear colourless viscous liquid
Purity:99%
Buy High Quality Top Purity 2-(Hydroxymethyl)-12-crown 4-Ether 75507-26-5 Safe Transportation
- Molecular Formula:C9H18O5
- Molecular Weight:206.239
- Appearance/Colour:clear colourless viscous liquid
- Vapor Pressure:4.36E-06mmHg at 25°C
- Refractive Index:n20/D 1.480(lit.)
- Boiling Point:343.9 °C at 760 mmHg
- PKA:14.17±0.10(Predicted)
- Flash Point:161.8 °C
- PSA：57.15000
- Density:1.054 g/cm3
- LogP:-0.57270
2-(HYDROXYMETHYL)-12-CROWN 4-ETHER(Cas 75507-26-5) Usage
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Uses |
Ethylene oxide is important or critical to the production of detergents, thickeners, solvents, plastics, and various organic chemicals such as ethylene glycol, ethanolamines, simple and complex glycols, polyglycol ethers and other compounds. |
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Purification Methods |
Purify it by chromatography on Al2O3 with EtOAc as eluent to give a hygroscopic colourless oil, which is distilled under high vacuum and is distilled in vacuo. It has IR: 3418 (OH) and 1103 (COC) cm-1, NMR: max 3.70s. [Kimura et al. J Chem Soc, Chem Commun 492 1983, Pugia et al. J Org Chem 52 2617 1987.] S -(-)-5-Hydroxymethyl -2(5 H )-furanone [78508-96 -0] M 114.1, 39 -42o, 40 -44o , b 1 3 0o/0.3mm, [ ] 546 -180o, [ ] D -148o (c 1.4, H2O). It is purified by chromatography on Silica gel using hexane/EtOAc (1:1) to give a colourless oil which is distilled using a Kügelrohr apparatus, and the distillate crystallises on cooling. It has RF 0.51 on Whatman No 1 paper using pentan-1-ol and 85% formic acid (1:1) and developing with ammoniacal AgNO3. [Boll Acta Chem Scand 22 3245 1968, NMR: Oppolzer et al. Helv Chim Acta 68 2100 1985, Beilstein 18 III/IV 56, 18/1 V 54.] |
InChI:InChI=1/C9H18O5/c10-7-9-8-13-4-3-11-1-2-12-5-6-14-9/h9-10H,1-8H2
75507-26-5 Relevant articles
Facile Synthesis of Hydroxymethylcrown Ethers
Ikeda, Isao,Emura, Hiroshi,Okahara, Mitsuo
, p. 73 - 74 (2007/10/02)
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Synthesis and Alkali-cation Complexing Properties of 12-Crown-4 Derivatives
Miyazaki, Takeshi,Yanagida, Shozo,Itoh, Akira,Okahara, Mitsuo
, p. 2005 - 2009 (2007/10/02)
Benzyloxymethyl-12-crown-4, a precursor ...
Synthesis of Substituted Crown Ethers from Oligoethylene Glycols
Ikeda, Isao,Yamamura, Shingo,Nakatsuji, Yohji,Okahara, Mitsuo
, p. 5355 - 5358 (2007/10/02)
A convenient synthetic method for prepar...
75507-26-5 Process route
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- 75507-20-9
<(Benzyloxy)methyl>-12-crown-4
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- 75507-26-5
2-(hydroxymethyl)-12-crown-4
| Conditions | Yield |
|---|---|
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With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In 1,4-dioxane; for 3h; Ambient temperature;
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97% |
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With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In 1,4-dioxane; at 50 ℃; for 5h;
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81% |
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- 90655-78-0
<(Allyloxy)-methyl>-12-crown-4
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- 75507-26-5
2-(hydroxymethyl)-12-crown-4
| Conditions | Yield |
|---|---|
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With perchloric acid; palladium on activated charcoal; In ethanol; at 80 ℃; for 24h;
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90% |
75507-26-5 Upstream products
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90655-78-0
<(Allyloxy)-methyl>-12-crown-4
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75507-20-9
<(Benzyloxy)methyl>-12-crown-4
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